MARCH4,膜相关环指蛋白4抗体

产品编号HZ-9338R
英文名称MARCH4
中文名称膜相关环指蛋白4抗体
别 名E3 ubiquitin protein ligase MARCH4; RNF174; KIAA1399; MARCH 4; MARCH IV; Membrane associated RING CH protein IV; Membrane associated ring finger (C3HC4) 4; Membrane associated RING finger protein 4; mKIAA1399; RING finger protein 174; MARH4_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 通道蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
MARCH4,膜相关环指蛋白4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量43kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human MARCH4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
MARCH4,膜相关环指蛋白4抗体PubMedPubMed
产品介绍background:
MARCH4, an E3 ubiquitin protein ligase, may mediate ubiquitination of MHC I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin protein ligases accept ubiquitin from an E2 ubiquitin conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Function:
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Subcellular Location:
Golgi apparatus membrane; Multipass membrane protein.

Tissue Specificity:
Expressed in brain and placenta.

Similarity:
Contains 1 RING-CH-type zinc finger.

Gene ID:
57574

Database links:
Entrez Gene: 57574 Human
Entrez Gene: 381270 Mouse
Entrez Gene: 367295 Rat
Omim: 608208 Human
SwissProt: Q9P2E8 Human
SwissProt: Q80TE3 Mouse

MARCH4,膜相关环指蛋白4抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.