MEPE,细胞外基质***酸化抗体

产品编号HZ-8689R
英文名称MEPE
中文名称细胞外基质***酸化抗体
别 名Matrix extracellular phosphoglycoprotein; MEPE; MEPE_HUMAN; OF45; Osteoblast/osteocyte factor 45.
说 明 书0.1ml 0.2ml
研究领域免疫学 发育生物学 信号转导 细胞外基质
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human,
MEPE,细胞外基质***酸化抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量56kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human MEPE
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
MEPE,细胞外基质***酸化抗体PubMedPubMed
产品介绍background:
MEPE is a 525 amino acid extracellular matrix protein. Expressed in osteocytes and brain, MEPE is a regulator of bone metabolism that is thought to mediate mineralization and demineralization within the osteocyte microenvironment. MEPE contains an RGD cell-attachment motif and shares molecular similarities with several dentin-bone extracellular matrix RGD-containing phosphoglycoproteins, including OPN (osteopontin) and DSP (dentin sialophosphoprotein). Via its ability to control bone mineralization, MEPE is associated with various developmental events such as skeletogenesis, bone regeneration and odontogenesis. MEPE is secreted in hypophosphatemic osteomalacia tumors, suggesting a possible role in the pathophysiology of bone-related cancers.

Function:
Seems to play a role in mineralization.

Subcellular Location:
Secreted

Tissue Specificity:
Expressed by osteoblasts. Secreted from oncogenic hypophosphataemic tumors.

Post-translational modifications:
Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif.

Gene ID:
56955

Database links:
Entrez Gene: 56955 Human
Entrez Gene: 94111 Mouse
Entrez Gene: 79110 Rat
Omim: 605912 Human
SwissProt: Q9NQ76 Human
Unigene: 676357 Human
Unigene: 196672 Mouse
Unigene: 160717 Rat

MEPE,细胞外基质***酸化抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.