HECA,HECA蛋白抗体

产品编号HZ-9702R
英文名称HECA
中文名称HECA蛋白抗体
别 名HDCL; Gm869; HDC; HDC_HUMAN; Headcase homolog (Drosophila); Headcase protein homolog; HECA; hHDC.
说 明 书0.1ml 0.2ml
研究领域肿瘤 心血管 细胞生物 免疫学 神经生物学 细胞周期蛋白 细胞分化 肿瘤细胞生物标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
HECA,HECA蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量59kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human HECA
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
HECA,HECA蛋白抗体PubMedPubMed
产品介绍background:
HECA, also known as headcase homolog, HDC, HDCL or HHDC, is a 543 amino acid mammalian homolog of the Drosophila headcase protein, a highly basic, cytplasmic peptide that plays a role in mitotic re-entry during adult morphogenesis. Expressed in a variety of tissues with highest expression in thymus, spleen and heart, HECA is thought to play a role in the development of epithelial tube networks in lung tissue and may also be involved in the pathogenesis of lung cancer. The gene encoding HECA maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.

Function:
May play an important role in some human cancers. May bepart of the regulatory mechanism in the development of epithelialtube networks such as the circulatory system and lungs.

Tissue Specificity:
Expressed in all tissues examined. Highest levels are in the spleen, thymus, peripheral blood and heart. Lowest in the kidney and pancreas.

Database links:
Entrez Gene: 51696 Human
Entrez Gene: 380629 Mouse
Entrez Gene: 308624 Rat
Omim: 607977 Human
SwissProt: Q9UBI9 Human
Unigene: 197644 Human
Unigene: 473073 Mouse

HECA,HECA蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.