FGF12,成纤维细胞生长因子12抗体

产品编号HZ-9760R
英文名称FGF12
中文名称成纤维细胞生长因子12抗体
别 名FGF-12; Fgf12; FGF12_HUMAN; FGF12B; FHF-1; FHF1; Fibroblast growth factor 12; Fibroblast growth factor 12B; Fibroblast growth factor FGF 12b; Fibroblast growth factor homologous factor 1; Myocyte activating factor; Myocyte-activating factor.
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 信号转导 生长因子和***
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
FGF12,成纤维细胞生长因子12抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量27kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human FGF12
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FGF12,成纤维细胞生长因子12抗体PubMedPubMed
产品介绍background:
Fibroblast growth factor-1 (FGF-1), also designated acidic FGF, and fibroblast growth factor-2 (FGF-2), also designated basic FGF, are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithe-lial and neuroectodermal origin. Additional members of the FGF family include the oncogenes FGF-3 (Int2) and FGF-4 (hst/Kaposi), FGF-5, FGF-6, FGF-7 (KGF), FGF-8 (AIGF), FGF-9 (GAF) and FGF-10–FGF-23. Members of the FGF family share 30-55% amino acid sequence identity and similar gene structure, and are capable of transforming cultured cells when overexpressed in transfected cells. Cellular receptors for FGFs are members of a second multigene family including four tyrosine kinases, designated Flg (FGFR-1), Bek (FGFR-L), TKF and FGFR-3.

Function:
Probably involved in nervous system development and function.

Subunit:
Interacts with the C-terminal region of SCN9A (By similarity).

Subcellular Location:
Nucleus.

Tissue Specificity:
Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures.

Database links:
Entrez Gene: 2257 Human
Entrez Gene: 14167 Mouse
Entrez Gene: 170630 Rat
Omim: 601513 Human
SwissProt: P61328 Human
SwissProt: P61329 Mouse
SwissProt: P61150 Rat
Unigene: 390250 Human
Unigene: 7996 Mouse
Unigene: 45965 Rat

FGF12,成纤维细胞生长因子12抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.