TET1,Ten-eleven转运基因1蛋白抗体

产品编号HZ-8523R
英文名称TET1
中文名称Ten-eleven转运基因1蛋白抗体
别 名Leukemia associated protein with a CXXC domain; CXXC 6; CXXC finger 6; CXXC type zinc finger protein 6; CXXC-type zinc finger protein 6; CXXC6; KIAA1676; LCX; Leukemia-associated protein with a CXXC domain; Methylcytosine dioxygenase TET1; Ten eleven translocation 1 gene protein; Ten eleven translocation 1 gene protein homolog; Ten-eleven translocation 1 gene protein; Tet 1; Tet oncogene 1; TET1; TET1_HUMAN; TET1/CXXC6.
说 明 书0.1ml 0.2ml
研究领域肿瘤 干细胞 转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
TET1,Ten-eleven转运基因1蛋白抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量235kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human TET1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
TET1,Ten-eleven转运基因1蛋白抗体PubMedPubMed
产品介绍background:
TET1 (tet oncogene 1), also known as LCX or CXXC6, is a 2,136 amino acid protein that localizes to the nucleus and contains one CXXC-type zinc finger. Expressed in adult ovary, thymus and skeletal muscle and also present in fetal lung, heart and brain, TET1 is thought to play a role in the development of fetal organs and may also be involvement in the pathoegenesis and metastasis of acute myeloid leukemia (AML). The gene encoding TET1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.

Subunit:
Interacts with SIN3A; recruits the transcriptional co-repressor SIN3A to gene promoters.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in fetal heart, lung and brain, and in adult skeletal muscle, thymus and ovary.

TET1,Ten-eleven转运基因1蛋白抗体Similarity:
Belongs to the TET family.
Contains 1 CXXC-type zinc finger.

Gene ID:
80312

Database links:
Entrez Gene: 80312 Human
Entrez Gene: 52463 Mouse
Entrez Gene: 309902 Rat
Omim: 607790 Human
SwissProt: Q8NFU7 Human
SwissProt: Q3URK3 Mouse
Unigene: 567594 Human
Unigene: 708977 Human
Unigene: 17774 Mouse

TET1,Ten-eleven转运基因1蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片

Tissue/cell: human laryngocarcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;  Incubation: Anti-TET1 Polyclonal Antibody, Unconjugated(HZ-8523R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: mouse embryo tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;  Incubation: Anti-TET1 Polyclonal Antibody, Unconjugated(HZ-8523R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining