OIF,骨诱导因子抗体

产品编号HZ-9407R
英文名称OIF
中文名称骨诱导因子抗体
别 名Corneal keratan sulfate proteoglycan; MIME_HUMAN; mimecan; Mimecan proteoglycan; OG; OGN; OIF; osteoglycin; osteoinductive factor; SLRR3A.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 细胞分化 细胞骨架 细胞外基质
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
OIF,骨诱导因子抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量31kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human OIF
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
OIF,骨诱导因子抗体PubMedPubMed
产品介绍background:
The small leucine-rich proteoglycan (SLRP) family of proteins contains various proteins such as Decorin, Biglycan, Fibromodulin, Keratocan, Lumican, Osteoadherin and Osteoglycin. These proteins all have similar functions as they all mediate extracellular matrix organization and act as binding partners of TGF beta. Osteoglycin, which also may be designated osteoinductive factor (OIF), is a secreted protein detected in bone tissues. Osteoglycin induces the formation of bone in conjunction with either TGF-beta-1 or TGF-beta-2. The precursor form of the OGN gene product, designated Mimecan, is subject to in situ proteolytic cleavage to yield the mature Osteoglycin.

Function:
Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Tissue Specificity:
Bone.

OIF,骨诱导因子抗体Post-translational modifications:
N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.

Similarity:
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
Contains 7 LRR (leucine-rich) repeats.

Gene ID:
4969

Database links:
Entrez Gene: 4969 Human
Omim: 602383 Human
SwissProt: P20774 Human
Unigene: 109439 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.