HABP2,透明质酸结合蛋白2抗体

产品编号HZ-9911R
英文名称HABP2
中文名称透明质酸结合蛋白2抗体
别 名Hyaluronan-binding protein 2 27 kDa light chain; Factor seven activating protease; Factor seven-activating protease; Factor VII activating protein; Factor VII-activating protease; FSAP; HABP 2; HABP; Habp2; HABP2_HUMAN; Hepatocyte growth factor activator like protein; Hepatocyte growth factor activator-like protein; HGFAL; Hyaluronan binding protein 2; Hyaluronic acid binding protein 2; PHBP; Plasma hyaluronan binding protein; Plasma hyaluronan-binding protein.
说 明 书0.1ml 0.2ml
研究领域心血管
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
HABP2,透明质酸结合蛋白2抗体产品应用WB=1:100-500 IHC-P=1:100-500 IHC-F=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量27kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from humsn Hyaluronan-binding protein 2 27 kDa light chain
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
HABP2,透明质酸结合蛋白2抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Function:
Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII.

Subunit:
Heterodimer; disulfide-linked. Heterodimer of a 50 kDa heavy and a 27 kDa light chain linked by a disulfide bond.

Subcellular Location:
Secreted. Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.

Tissue Specificity:
Ubiquitously expressed.

Post-translational modifications:
Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain and cleavage at Arg-313 or Lys-319 can give rise to the 27 kDa light chain. The heavy chain can undergo further proteolytic cleavage at Lys-169 or Arg-170 to give rise to 2 inactive 26 kDa fragments and the light chain can undergo further proteolytic cleavage at Arg-480 to give rise to inactive 17 kDa and 8 kDa fragments.

HABP2,透明质酸结合蛋白2抗体Similarity:
Belongs to the peptidase S1 family.
Contains 3 EGF-like domains.
Contains 1 kringle domain.
Contains 1 peptidase S1 domain.

Gene ID:
3026

Database links:
Entrez Gene: 3026 Human
Entrez Gene: 226243 Mouse
Entrez Gene: 292126 Rat
Omim: 603924 Human
SwissProt: Q5E9Z2 Cow
SwissProt: Q14520 Human
SwissProt: Q8K0D2 Mouse
SwissProt: Q6L711 Rat
Unigene: 422542 Human
Unigene: 25791 Mouse
Unigene: 161908 Rat

HABP2,透明质酸结合蛋白2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.