KLHL36,Kelch样蛋白36抗体

产品编号HZ-9628R
英文名称KLHL36
中文名称Kelch样蛋白36抗体
别 名Kelch like 36; Kelch like protein 36; kelch-like 36 (Drosophila); Kelch-like protein 36; KLH36_HUMAN; KLHL 36; KLHL-36.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 泛素
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
KLHL36,Kelch样蛋白36抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量70kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human KLHL36/C16orf44
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
KLHL36,Kelch样蛋白36抗体PubMedPubMed
产品介绍background:
C16orf44 is a 616 amino acid protein that contains six Kelch repeats, one BTB/POZ domain and one BTB/Kelch associated (BACK) domain. C16orf44 is believed to play a role in protein ubiquitination and may function as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, C16orf44 interacts with CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Due to alternative splicing events, two isoforms of C16orf44 are expressed.

Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Subunit:
Interacts with CUL3.

Similarity:
Contains 1 BACK (BTB/Kelch associated) domain.
Contains 1 BTB (POZ) domain.
Contains 6 Kelch repeats.

Gene ID:
79786

Database links:
Entrez Gene: 79786 Human
Entrez Gene: 234796 Mouse
Entrez Gene: 498957 Rat
SwissProt: Q8N4N3 Human
SwissProt: Q8R124 Mouse
SwissProt: Q66HD2 Rat
Unigene: 578546 Human
Unigene: 86446 Mouse
Unigene: 139361 Rat

KLHL36,Kelch样蛋白36抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.