PCDHA9,原钙粘附蛋白α9抗体
英文名称: Anti-PCDHA9 antibody
型号:null    抗体货号: HZ-11120R
价格:请致电:010-57128832,18610462672
品牌: 中国/美国    产品商标: hzbscience

PCDHA9,原钙粘附蛋白α9抗体

产品编号HZ-11120R
英文名称PCDHA9
中文名称原钙粘附蛋白α9抗体
别 名KIAA0345; PCDH alpha 9; Protocadherin alpha 9; PCDA9_HUMAN; Protocadherin alpha-9; PCDH-alpha-9.
说 明 书0.1ml 0.2ml
研究领域神经生物学 信号转导 细胞粘附分子 细胞骨架 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow,
PCDHA9,原钙粘附蛋白α9抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量102kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human PCDHA6
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PCDHA9,原钙粘附蛋白α9抗体PubMedPubMed
产品介绍background:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDHA9 (protocadherin alpha 9), also known as KIAA0345, is a 950 amino acid single-pass type I membrane protein that contains six cadherin domains and is encoded by a gene which is located within the protocadherin alpha gene cluster on human chromosome 5. Existing as multiple alternatively spliced isoforms, PCDHA9 functions as a potential calcium-dependent cell adhesion protein that may be involved in the establishment and maintenance of neuronal connections within the brain.

Function:
RelevancePotential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein

Similarity:
Contains 6 cadherin domains.

Database links:
UniProtKB/Swiss-Prot: Q9Y5H5.1

PCDHA9,原钙粘附蛋白α9抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).

Subunit:
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily. Contains 1 RCK N-terminal domain.

Subcellular Location:
Membrane.

Tissue Specificity:
Widely expressed. Except in myocytes, it is almost ubiquitously expressed.

Post-translational modifications:
Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity.

KCNMA1/BK channel,钙激活钾通道蛋白α1抗体DISEASE:
Defects in KCNMA1 are the cause of generalized epilepsy and paroxysmal dyskinesia (GEPD) [MIM:609446]. Epilepsy is one of the most common and debilitating neurological disorders. Paroxysmal dyskinesias are neurological disorders characterized by sudden, unpredictable, disabling attacks of involuntary movement often requiring life-long treatment. The coexistence of epilepsy and paroxysmal dyskinesia in the same individual or family is an increasingly recognized phenomenon. Patients manifest absence seizures, generalized tonic-clonic seizures, paroxysmal nonkinesigenic dyskinesia, involuntary dystonic or choreiform movements. Onset is usually in childhood and patients may have seizures only, dyskinesia only, or both.

Similarity:
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
Contains 1 RCK N-terminal domain.

Database links:
Entrez Gene: 374065 Chicken
Entrez Gene: 282573 Cow
Entrez Gene: 403984 Dog
Entrez Gene: 3778 Human
Entrez Gene: 16531 Mouse
Entrez Gene: 83731 Rat
Omim: 600150 Human
SwissProt: Q8AYS8 Chicken
SwissProt: Q28204 Cow
SwissProt: Q28265 Dog
SwissProt: Q12791 Human
SwissProt: Q08460 Mouse
SwissProt: Q9BG98 Rabbit
SwissProt: Q62976 Rat
Unigene: 144795 Human
Unigene: 343607 Mouse
Unigene: 486347 Mouse
Unigene: 30616 Rat

KCNMA1/BK channel,钙激活钾通道蛋白α1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.