Neurexin II alpha,轴突蛋白2抗体

产品编号HZ-11104R
英文名称Neurexin II alpha
中文名称轴突蛋白2抗体
别 名Neurexin 2; Neurexin-2; Neurexin2; Neurexin II; Neurexin II alpha; NRXN 2; NRXN-2; NRXN2; NRX2A_HUMAN.
说 明 书0.1ml 0.2ml
研究领域神经生物学 细胞粘附分子 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
Neurexin II alpha,轴突蛋白2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量182kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Neurexin 2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Neurexin II alpha,轴突蛋白2抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]

Function:
Neurexin 2 alpha belongs to the Neurexin family, a group of neuronal proteins that function as cell adhesion molecules during synaptogenesis and intracellular signaling. Mammalian genomes contain just three neurexin genes. However, many neurexin isoforms may be expressed through the use of two alternative promoters and alternative splicing at up to five different positions.

Subunit:
The laminin G-like domain 1 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan. Interacts with INADL.

Subcellular Location:
Membrane; single-pass type I membrane protein.

Tissue Specificity:
Predominantly expressed in brain.

Neurexin II alpha,轴突蛋白2抗体Similarity:
Belongs to the neurexin family.
Contains 3 EGF-like domains.
Contains 6 laminin G-like domains.

Gene ID:
9379

Database links:
Entrez Gene: 9379 Human
Entrez Gene: 18190 Mouse
Entrez Gene: 116595 Rat
SwissProt: Q9P2S2 Human
SwissProt: Q63374 Rat
Unigene: 372938 Human
Unigene: 329616 Mouse
Unigene: 414022 Mouse
Unigene: 11282 Rat

Neurexin II alpha,轴突蛋白2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.