MDGA2,神经元膜糖蛋白锚定蛋白2抗体

产品编号HZ-11092R
英文名称MDGA2
中文名称神经元膜糖蛋白锚定蛋白2抗体
别 名MAM domain-containing glycosylphosphatidylinositol anchor protein 2; MAM domain-containing protein 1; MAMDC1; Mdga2; MDGA2_HUMAN; UNQ8188/PRO23197; c14_5286.
说 明 书0.1ml 0.2ml
研究领域神经生物学 信号转导 细胞凋亡 细胞粘附分子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
MDGA2,神经元膜糖蛋白锚定蛋白2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量102kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human MDGA2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
MDGA2,神经元膜糖蛋白锚定蛋白2抗体PubMedPubMed
产品介绍background:
MDGA2 is a cell membrane protein which contains six Ig-like (immunoglobulin-like) domains and one MAM domain. Analyses of the full-length coding region of MDGA1 and MDGA2 indicate that they encode proteins that comprise a novel subgroup of the Ig superfamily and have a unique structural organization consisting of six immunoglobulin (Ig)-like domains followed by a single MAM domain. Biochemical characterization demonstrates that MDGA1 and MDGA2 proteins are highly glycosylated, and that MDGA1 is tethered to the cell membrane by a GPI anchor. The MDGAs are differentially expressed by subpopulations of neurons in both the central and peripheral nervous systems, including neurons of the basilar pons, inferior olive, cerebellum, cerebral cortex, olfactory bulb, spinal cord, and dorsal root and trigeminal ganglia. The similarity of MDGAs to other Ig-containing molecules and their temporal-spatial patterns of expression within restricted neuronal populations, for example migrating pontine neurons and D1 spinal interneurons, suggest a role for these novel proteins in regulating neuronal migration, as well as other aspects of neural development, including axon guidance.

Function:
May involved in cell-cell interactions.

Subcellular Location:
Cell membrane.

MDGA2,神经元膜糖蛋白锚定蛋白2抗体Similarity:
Contains 6 Ig-like (immunoglobulin-like) domains. Contains 1 MAM domain.

Database links:
UniProtKB/Swiss-Prot: Q7Z553.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.