INSL3,胰岛素样蛋白3抗体

产品编号HZ-11301R
英文名称INSL3
中文名称胰岛素样蛋白3抗体
别 名INSL 3; INSL-3; INSL3_HUMAN; *** like 3; ***-like 3 A chain; Ley IL; Ley-I-L; Leydig insulin like peptide; Leydig insulin-like peptide; Relaxin like factor; Relaxin-like factor; RLF; RLNL.
说 明 书0.1ml 0.2ml
研究领域免疫学 信号转导 生长因子和***
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human,
INSL3,胰岛素样蛋白3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量3kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human INSL3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
INSL3,胰岛素样蛋白3抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012].

Function:
Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

Subunit:
Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum, trophoblast, fetal membranes and breast.

DISEASE:
Defects in INSL3 seems to be a cause of cryptorchidism (CRYPTO) [MIM:219050]; also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. The frequency of INSL3 gene mutations as a cause of cryptorchidism is low.

INSL3,胰岛素样蛋白3抗体Similarity:
Belongs to the insulin family.

Database links:
UniProtKB/Swiss-Prot: P51460.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.