Synaptogyrin 2,神经细胞囊泡循环蛋白2抗体
英文名称: Anti-Synaptogyrin 2 antibody
型号:null    抗体货号: HZ-11374R
价格:请致电:010-57128832,18610462672
品牌: 中国/美国    产品商标: hzbscience

Synaptogyrin 2,神经细胞囊泡循环蛋白2抗体

产品编号HZ-11374R
英文名称Synaptogyrin 2
中文名称神经细胞囊泡循环蛋白2抗体
别 名Cellugyrin; MGC102914; SNG2_HUMAN; Synaptogyrin-2; Synaptogyrin2; SYNGR 2; SYNGR-2; SYNGR2.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Sheep,
Synaptogyrin 2,神经细胞囊泡循环蛋白2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量25kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Synaptogyrin 2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Synaptogyrin 2,神经细胞囊泡循环蛋白2抗体PubMedPubMed
产品介绍background:
The synaptogyrin family of proteins are integral membrane proteins containing four transmembrane regions. Synaptogyrins are tyrosine-phosphorylated proteins with two neuronal (Synaptogyrin-1 and -3) and one ubiquitous (Synaptogyrin-2) isoform. Synaptophysin and synaptogyrin represent the major constituents of synaptic vesicles. Synaptogyrin-1 is associated with presynaptic vesicles in neuronal cells. Synaptogyrin-2, also known as cellugyrin, has a tyrosine phosphorylated C-terminal cytoplasmic tail and is involved in the regulation of membrane traffic in non-neuronal cells. Synaptogyrin-3 is expressed mainly in brain and placenta.

Subcellular Location:
Membrane; Multi-pass membrane protein. Cytoplasmic vesicle (By similarity).

Tissue Specificity:
Ubiquitous; low expression in brain.

Similarity:
Belongs to the synaptogyrin family.
Contains 1 MARVEL domain.

Synaptogyrin 2,神经细胞囊泡循环蛋白2抗体Database links:
UniProtKB/Swiss-Prot: O43760.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

g>Tissue Specificity:
High levels in heart, ovary, pancreas and skeletal muscle.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Phosophorylation at Ser-410 by PKA severely impairs binding to OCRL.

Similarity:
Contains 1 PH domain.
Contains 1 PID domain.

Gene ID:
26060

Database links:
Entrez Gene: 26060 Human
Entrez Gene: 72993 Mouse
Entrez Gene: 290537 Rat
Omim: 604299 Human
SwissProt: Q9UKG1 Human
SwissProt: Q8K3H0 Mouse
Unigene: 476415 Human
Unigene: 202322 Mouse


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

衔接因子蛋白含pH域***酸酪氨酸结合域和亮氨酸拉链基元1抗体.
APPL1可调节脂联素和胰岛素信号,是细胞膜与细胞核之间重要的信息传递蛋白,同时也是细胞增殖所必需的蛋白,它有调节脂联素在脂肪酸氧化和葡萄糖吸收中的作用,APPL1通过激酶通道来调节脂联素的胰岛素敏感效应。

产品图片
Tissue/cell: Rat ovary tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; 
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; 
Incubation: Anti-APPL1 Polyclonal Antibody, Unconjugated(bs-1632R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining