CD361,CD361抗体

产品编号HZ-14684R
英文名称CD361
中文名称CD361抗体
别 名EVI2B; CD361; D17S376; Ecotropic viral integration site 2B; Ecotropic viral integration site 2B protein homolog; EVDB; EVI 2B; EVI-2B; Evi2b; EVI2B protein; EVI2B_HUMAN; Protein EVI2B.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 神经生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,
CD361,CD361抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量46kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CD361
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD361,CD361抗体PubMedPubMed
产品介绍background:
EVI2B is a 448 amino acid protein which functions in the differentiation of melanocytes and keratinocytes. Lying within an intron of the Neurofibromin gene, the gene encoding EVI2B is transcribed from the telomere toward the centromere, which is opposite the transcription direction of the Neurofibromin gene. EVI2B is a single-pass transmembrane protein containing an extracellular domain with 4 glycosylation sites, a N-terminal signal peptide, a cytoplasmic hydrophilic domain and a hydrophobic transmembrane domain. Due to evidence suggesting that gene encoding the mouse homolog lies within a viral integration site that has been identitified in retrovirus-induced myeloid tumors, the gene encoding EVI2B may function as an oncogene in these tumor types. With expression in peripheral blood mononuclear cells, fibroblasts, bone marrow and EBV-transformed lymphoblastoid cell lines, EVI2B is implicated in leukemogenesis.

Subcellular Location:
Membrane.

Tissue Specificity:
Bone marrow, peripheral blood mononuclear cells, fibroblasts and Epstein-Barr virus-transformed lymphoblastoid cell lines.

Gene ID:
2124

Database links:
Entrez Gene: 2124 Human
Omim: 158381 Human
SwissProt: P34910 Human
Unigene: 5509 Human

CD361,CD361抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.