C9orf95/NRK,9号染色体开放阅读框95抗体

产品编号HZ-15349R
英文名称C9orf95/NRK
中文名称9号染色体开放阅读框95抗体
别 名bA235O14.2; C9orf95; Chromosome 9 open reading frame 95; FLJ20559; Nicotinamide riboside kinase 1; Nicotinic acid riboside kinase 1; NmR-K 1; NRK 1; NRK1; NRK1_HUMAN; Ribosylnicotinamide kinase 1; Ribosylnicotinic acid kinase 1; RNK 1; RP11-235O14.2.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 信号转导 新陈代谢
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Sheep,
C9orf95/NRK,9号染色体开放阅读框95抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量23kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human C9orf95
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
C9orf95/NRK,9号染色体开放阅读框95抗体PubMedPubMed
产品介绍background:
Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor involved in fundamental processes in cell metabolism. NRK1 (Nicotinamide riboside kinase 1), also known as Ribosylnicotinamide kinase 1, is a 199 amino acid enzyme is involved in the synthesis of NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor. Nicotinamide riboside has been idenitifed as a nutrient in milk, suggesting that it is a useful compound for elevating the NAD+ levels in humans. NRK1 also phosphorylates the anti-cancer drugs tiazofurin and 3-deazaguanosine, which converts them into toxic NAD+ analogs and leads to the inhibition of guanine nucleotide biosynthesis. There are two isoforms of NRK1 that are produced as a result of alternative splicing events.

Function:
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.

Subunit:
Monomer.

Similarity:
Belongs to the uridine kinase family. NRK subfamily.

Gene ID:
54981

C9orf95/NRK,9号染色体开放阅读框95抗体Database links:
Entrez Gene: 54981 Human
Entrez Gene: 499330 Rat
Omim: 608704 Human
SwissProt: Q9NWW6 Human
SwissProt: Q6AY91 Rat
Unigene: 494186 Human
Unigene: 19716 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.