AX2R,膜粘连蛋白2受体抗体

产品编号HZ-4969R
英文名称AX2R
中文名称膜粘连蛋白2受体抗体
别 名LOC389289; ANXA2R; Annexin 2 receptor; Annexin II receptor; AX2R; AXIIR; C5orf39; Chromosome 5 open reading frame 39; AX2R_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 细胞凋亡 细胞膜受体 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,
AX2R,膜粘连蛋白2受体抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量22kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human AX2R
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
AX2R,膜粘连蛋白2受体抗体PubMedPubMed
产品介绍background:
ANXA2R (annexin-2 receptor), also known as AX2R or C5orf39, is a 193 amino acid protein that is widely expressed and may act as an annexin II receptor on marrow stromal cells to induce osteoclast formation. In addition, ANXA2R is highly expressed in lymphocytes and is also found in resting CD4+ and CD8+ T cells. The gene encoding ANXA2R maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

Function:
May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.

Tissue Specificity:
Widely expressed. Highly expressed in lymphocytes. Expressed in both resting CD4(+) and CD8(+) T-cells.

Gene ID:
389289

Database links:
Entrez Gene: 389289 Human
Omim: 611296 Human
SwissProt: Q3ZCQ2 Human

AX2R,膜粘连蛋白2受体抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.