CKAP4,细胞骨架相关蛋白4抗体

产品编号HZ-6520R
英文名称CKAP4
中文名称细胞骨架相关蛋白4抗体
别 名p63; 63 kDa membrane protein; CKAP 4; CLIMP 63; CLIMP63; Cytoskeleton associated protein 4; ERGIC 63; ERGIC63; MGC99554; Transmembrane protein 63kD endoplasmic reticulum Golgi intermediate compartment; Type II transmembrane protein p63; CKAP4_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 肿瘤细胞生物标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Pig, Cow,
CKAP4,细胞骨架相关蛋白4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量66kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CKAP4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CKAP4,细胞骨架相关蛋白4抗体PubMedPubMed
产品介绍background:
CKAP4 is a substrate of DHHC2, a putative tumor suppressor. CK MNF116 and CKAP4 were useful in identifying squamous cell carcinomas with single cell infiltration. These results suggest a role for CKAP4 in tumor.

Function:
High-affinity epithelial cell surface receptor for APF.
Mediates the anchoring of the endoplasmic reticulum to microtubules.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear region upon APF-stimulation.

Post-translational modifications:
Reversibly palmitoylated. Palmitoylation at Cys-100 by DHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization.
Increased phosphorylation during mitosis prevents binding to microtubules.

CKAP4,细胞骨架相关蛋白4抗体Database links:
UniProtKB/Swiss-Prot: Q07065.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.