Dispatched,膜转运蛋白DISPA抗体

产品编号HZ-11549R
英文名称Dispatched
中文名称膜转运蛋白DISPA抗体
别 名DISP1; DISP 1; disp1; DISP1_HUMAN; DISPA; Dispatched A; Dispatched homolog 1; DKFZP434I0428; FLJ43740; MGC104180; MGC13130; MGC16796; Protein dispatched homolog 1.
说 明 书0.1ml 0.2ml
研究领域信号转导 转运蛋白 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, Sheep,
Dispatched,膜转运蛋白DISPA抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量171kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Dispatched (301-400aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Dispatched,膜转运蛋白DISPA抗体PubMedPubMed
产品介绍background:
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]

Function:
Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal

Subcellular Location:
Membrane; Multi-pass membrane protein

Similarity:
Belongs to the dispatched family.
Contains 1 SSD (sterol-sensing) domain.

Database links:
Entrez Gene: 84976 Human
Entrez Gene: 68897 Mouse
Omim: 607502 Human
SwissProt: Q96F81 Human
SwissProt: Q3TDN0 Mouse
Unigene: 528817 Human
Unigene: 358721 Mouse

Dispatched,膜转运蛋白DISPA抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.