ZNF318,пָµ°°×318¿¹Ìå
²úÆ·±àºÅHZ-11414R
Ó¢ÎÄÃû³ÆZNF318
ÖÐÎÄÃû³ÆÐ¿Ö¸µ°°×318¿¹Ìå
±ð ÃûEndocrine Regulatory Protein; HGNC13578; HRIHFB2436; ZFP318; Zinc Finger Protein 318; ZN318_HUMAN.
˵ Ã÷ Êé0.1ml 0.2ml
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¿¹ÌåÀ´Ô´Rabbit
¿Ë¡ÀàÐÍPolyclonal
½»²æ·´Ó¦ Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,
ZNF318,пָµ°°×318¿¹Ìå²úÆ·Ó¦ÓÃWB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 £¨Ê¯À¯ÇÐÆ¬Ðè×ö¿¹ÔÐÞ¸´£©
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
·Ö ×Ó Á¿251kDa
ϸ°û¶¨Î»Ï¸°ûºË
ÐÔ ×´Lyophilized or Liquid
Ũ ¶È1mg/1ml
Ãâ Òß ÔKLH conjugated synthetic peptide derived from human ZNF318 (1077-1125aa)
ÑÇ ÐÍIgG
´¿»¯·½·¨affinity purified by Protein A
´¢ ´æ Òº0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
±£´æÌõ¼þStore at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ZNF318,пָµ°°×318¿¹ÌåPubMedPubMed
²úÆ·½éÉÜbackground:
ZNF318 is a 2279 amino acid endocrine regulatory protein that localizes to the nucleus. Highly expressed in testis, ovaries and kidneys, ZNF318 is a co-repressor of androgen receptor (AR)-mediated transcriptional activation and is thought to regulate transcription during spermatogenesis. ZNF318 interacts with the N-terminal domain of AR and contains two matrin-type zinc fingers. Two isoforms of ZNF318, designated TZF and TZF-L, are produced due to alternative splicing events. Each of these splice variants are thought to have unique roles in transcriptional regulation. While the TZF isoform functions as a repressor of AR-mediated transcriptional activation, the TZF-L isoform is thought to enhance AR-mediated transcriptional activation.
Function:
ZNF318 encodes a nuclear protein with a zinc finger motif of the Cys2-His2 type that is a novel corepressor of androgen receptor.
Subunit:
Interacts with the N-terminal domain of AR.
Subcellular Location:
Nuclear.
Tissue Specificity:
Expressed in endocrine tissue.
ZNF318,пָµ°°×318¿¹ÌåPost-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Contains 2 matrin-type zinc fingers.
Gene ID:
24149
Database links:
Entrez Gene: 24149 Human
SwissProt: Q5VUA4 Human
SwissProt: Q99PP2 Mouse
Unigene: 509718 Human
ZNF318,пָµ°°×318¿¹ÌåImportant Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.