DHRS4L1,短链脱氢酶/还原酶家族4样1蛋白抗体
英文名称： Anti-DHRS4L1 antibody
型号:null    抗体货号： HZ-14309R
价格:请致电：010-57128832,18610462672
品牌: 中国/美国    产品商标: hzbscience

DHRS4L1,短链脱氢酶/还原酶家族4样1蛋白抗体

产品编号HZ-14309R
英文名称DHRS4L1
中文名称短链脱氢酶/还原酶家族4样1蛋白抗体
别 名DHRS4L1; DR4L1_HUMAN; Putative dehydrogenase/reductase SDR family member 4-like 2.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep,
DHRS4L1,短链脱氢酶/还原酶家族4样1蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量31kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DHRS4L1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DHRS4L1,短链脱氢酶/还原酶家族4样1蛋白抗体PubMedPubMed
产品介绍Function:
Putative oxidoreductase.

Similarity:
Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Gene ID:
728635

Database links:
Entrez Gene: 728635 Human
SwissProt: P0CG22 Human
Unigene: 647569 Human

DHRS4L1,短链脱氢酶/还原酶家族4样1蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

n. The CRMPs appear to play a complex role in axon growth as well as microtubule dynamics and axon induction. CRMPs localize to the lamellipodia and filopodia of axonal growth cones, suggesting a role in axon guidance. Moreover, CRMP2 is upregulated after axotomy, and appears to increase the formation of axon-type processes from hippocampal neurons. CRMP2 has been reported to bind tubulin dimers directly and modulate microtubule assembly. CRMPs have also been implicated in the pathogenesis of a paraneoplastic neurologic syndrome. Interaction studies have implicated phospholipase D2 (PLD2), the cytosolic tyrosine kinase Fes, and intersectin in CRMP function. Hyperphosphorylation of CRMP2 is an early event in the progression of Alzheimer's disease.

Function:
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Subunit:
Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5 (By similarity). Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin (By similarity).

Phospho-CRMP2 (Thr514),***酸化二氢嘧***酶样2抗体Subcellular Location:
Cytoplasm. Cell projection, growth cone. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.

Tissue Specificity:
Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.

Post-translational modifications:
Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.

Similarity:
Belongs to the DHOase family.

Gene ID:
1808

Database links:
Entrez Gene: 1808 Human
Entrez Gene: 12934 Mouse
Entrez Gene: 25416 Rat
Omim: 602463 Human
SwissProt: Q16555 Human
SwissProt: O08553 Mouse
SwissProt: P47942 Rat
Unigene: 173381 Human
Unigene: 352648 Mouse
Unigene: 475100 Mouse
Unigene: 2889 Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CRMP2是一种脑特异性蛋白，对于轴突生长和轴突-树突发育起到很重要的作用，CRMP2通过与微管蛋白二聚体结合并促进微管的组装来调控轴突的生长和分支。