CD27,CD27抗体

产品编号HZ-2491R
英文名称CD27
中文名称CD27抗体
别 名CD 27; Cd27; CD27 antigen; CD27 molecule; CD27_HUMAN; CD27L receptor; LPFS2; MGC20393; OTTHUMP00000238557; S152; T cell activation antigen CD27; T cell antivation antigen S152; T-cell activation antigen CD27; T14; TNFRSF 7; TNFRSF7; TNFSF7; Tp 55; Tp55; Tumor necrosis factor receptor superfamily member 7.
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 干细胞 细胞类型标志物 淋巴细胞 t-淋巴细胞 细胞因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow,
CD27,CD27抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量27kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CD27
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD27,CD27抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]

Function:
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

Subunit:
Homodimer. Interacts with SIVA1 and TRAF2.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Found in most T-lymphocytes.

Post-translational modifications:
Phosphorylated.
O-glycosylated with core 1 or possibly core 8 glycans.

CD27,CD27抗体Similarity:
Contains 3 TNFR-Cys repeats.

Gene ID:
939

Database links:
Entrez Gene: 939 Human
Entrez Gene: 21940 Mouse
Entrez Gene: 500318 Rat
Omim: 186711 Human
SwissProt: P26842 Human
SwissProt: P41272 Mouse
Unigene: 355307 Human
Unigene: 367714 Mouse
Unigene: 134200 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.