DNAJC10,Erdj5/DNAJC10蛋白抗体
产品编号HZ-1276R
英文名称DNAJC10
中文名称Erdj5/DNAJC10蛋白抗体
别 名DNAJC10; DnaJ (Hsp40) homolog subfamily C member 10; DnaJ homolog subfamily C member 10; DNAJC 10; ER resident protein ERdj5; ERdj 5; ERdj5; J domain containing protein disulfide isomerase like protein; JPDI; Macrothioredoxin; MGC104194; MTHr; DJC10_HUMAN; DnaJ homolog subfamily C member 10; ER-resident protein ERdj5; Macrothioredoxin; MTHr.
说 明 书0.1ml 0.2ml
研究领域信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
DNAJC10,Erdj5/DNAJC10蛋白抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量88kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DNAJC10
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DNAJC10,Erdj5/DNAJC10蛋白抗体PubMedPubMed
产品介绍background:
This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012].
Function:
This endoplasmic reticulum co-chaperone may play a role in protein folding and translocation across the endoplasmic reticulum membrane. May act as a co-chaperone for HSPA5.
Subunit:
Interacts with HSPA5 via its J domain.
Subcellular Location:
Secreted (Potential). Endoplasmic reticulum lumen.
Similarity:
Contains 1 J domain.
Contains 4 thioredoxin domains.
Gene ID:
54431
Database links:
Entrez Gene: 54431 Human
Omim: 607987 Human
SwissProt: Q8IXB1 Human
Unigene: 516632 Human
DNAJC10,Erdj5/DNAJC10蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ERdj5酶的功能就像一个“质检员”，能够识别出那些存在缺陷的蛋白质，并在这些蛋白质“上岗”前将其降解掉。由于降解的是蛋白质，而不是变异本身，因此过降解导致了变异型蛋白质CFTR降解，出现囊肿性纤维化病理改变（如：遗传性胰腺疾病）。