DNAJC10,Erdj5/DNAJC10蛋白抗体
英文名称： Anti-DNAJC10 antibody
型号:null    抗体货号： HZ-1276R
价格:请致电：010-57128832,18610462672
品牌: 中国/美国    产品商标: hzbscience

DNAJC10,Erdj5/DNAJC10蛋白抗体

产品编号HZ-1276R
英文名称DNAJC10
中文名称Erdj5/DNAJC10蛋白抗体
别 名DNAJC10; DnaJ (Hsp40) homolog subfamily C member 10; DnaJ homolog subfamily C member 10; DNAJC 10; ER resident protein ERdj5; ERdj 5; ERdj5; J domain containing protein disulfide isomerase like protein; JPDI; Macrothioredoxin; MGC104194; MTHr; DJC10_HUMAN; DnaJ homolog subfamily C member 10; ER-resident protein ERdj5; Macrothioredoxin; MTHr.
说 明 书0.1ml 0.2ml
研究领域信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
DNAJC10,Erdj5/DNAJC10蛋白抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量88kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DNAJC10
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DNAJC10,Erdj5/DNAJC10蛋白抗体PubMedPubMed
产品介绍background:
This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012].

Function:
This endoplasmic reticulum co-chaperone may play a role in protein folding and translocation across the endoplasmic reticulum membrane. May act as a co-chaperone for HSPA5.

Subunit:
Interacts with HSPA5 via its J domain.

Subcellular Location:
Secreted (Potential). Endoplasmic reticulum lumen.

Similarity:
Contains 1 J domain.
Contains 4 thioredoxin domains.

Gene ID:
54431

Database links:
Entrez Gene: 54431 Human
Omim: 607987 Human
SwissProt: Q8IXB1 Human
Unigene: 516632 Human

DNAJC10,Erdj5/DNAJC10蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ERdj5酶的功能就像一个“质检员”，能够识别出那些存在缺陷的蛋白质，并在这些蛋白质“上岗”前将其降解掉。由于降解的是蛋白质，而不是变异本身，因此过降解导致了变异型蛋白质CFTR降解，出现囊肿性纤维化病理改变（如：遗传性胰腺疾病）。

th factor receptors such as EGFR and INSR. Interacts with FLT1 (tyrosine-phosphorylated) (By similarity). Interacts with DOCK1 and DOCK4. Interacts with SHB. Interacts with PEAK1. Interacts with FASLG. Isoform Crk-II interacts with KIT. Interacts with EPHA3; upon activation of EPHA3 by the ligand EFNA5 and EPHA3 tyrosine kinase activity-dependent. Interacts with EPHA3 (phosphorylated); mediates EFNA5-EPHA3 signaling through RHOA GTPase activation. Interacts with FLT4 (tyrosine-phosphorylated). Isoform Crk-II (via SH2 domain) interacts with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and p130cas/BCAR1. Interacts (via SH2 domain) with the 'Tyr-9' phosphorylated form of PDPK1.

Subcellular Location:
Cytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion.

phospho-CRK (Tyr221),***酸化Crk p38抗体Post-translational modifications:
Phosphorylation of Crk-II (40 kDa) gives rise to a 42 kDa form. Isoform Crk-II is phosphorylated by KIT.
Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway.
Proline isomerization at Pro-237 by PPIA acts as a switch between two conformations: an autoinhibitory conformation in the cis form, where the tandem SH3 domains interact intramolecularly, and an activated conformation in the trans form.

Similarity:
Belongs to the CRK family.
Contains 1 SH2 domain.
Contains 2 SH3 domains.

Gene ID:
1398

Database links:
Entrez Gene: 1398 Human
Entrez Gene: 12928 Mouse
Entrez Gene: 54245 Rat
Omim: 164762 Human
SwissProt: P46108 Human
SwissProt: Q96GA9 Human
SwissProt: Q96HJ0 Human
SwissProt: Q64010 Mouse
SwissProt: Q63768 Rat
Unigene: 638121 Human
Unigene: 280125 Mouse
Unigene: 96136 Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.