CD72,CD72蛋白抗体
产品编号HZ-2517R
英文名称CD72
中文名称CD72蛋白抗体
别 名B-cell differentiation antigen CD72; CD72b; LYB2; B cell differentiation antigen CD72; CD72 antigen; CD72 molecule; CD72c; Ly-19; Ly-32; Ly-m19; Lyb-2; Lyb2; LYB2, mouse, homolog of; Lymphocyte antigen 32; MGC108873; CD72_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 干细胞 细胞表面分子 糖蛋白 细胞类型标志物 b-淋巴细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow,
CD72,CD72蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量40kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CD72 N-terminus
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD72,CD72蛋白抗体PubMedPubMed
产品介绍background:
CD72 antigen is a member of the type II integral membrane glycoproteins which includes other related cell surface molecules such as the asialoglycoprotein receptors, CD23 and the Kupffer cell receptor. The function of CD72 is unknown but the exposure of B cells to CD72 antibodies activates a variety of signaling pathways and can induce MHC class II expression and B cell proliferation. CD72 antigen is expressed on all cells of B cell lineage with the exception of plasma cells and weakly on human tissue macrophages.
Function:
Plays a role in B-cell proliferation and differentiation.
Subunit:
Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1 (By similarity).
Subcellular Location:
Membrane; Single-pass type II membrane protein.
Tissue Specificity:
Pre-B-cells and B-cells but not terminally differentiated plasma cells.
Post-translational modifications:
Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1 (By similarity).
Similarity:
Contains 1 C-type lectin domain.
Gene ID:
971
CD72,CD72蛋白抗体Database links:
Entrez Gene: 971 Human
Omim: 107272 Human
SwissProt: P21854 Human
Unigene: 116481 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CD72是一个重要的B细胞特异性受体。属于II型膜内糖蛋白成员中的细胞表面分子非唾液酸糖蛋白受体,虽然其分子功能目前还不清楚,但目前发现CD72的多态性与多种肿瘤有关。