CLEC2D,CLEC2D蛋白抗体

产品编号HZ-2683R
英文名称CLEC2D
中文名称CLEC2D蛋白抗体
别 名C-type lectin domain family 2 member D; C type lectin domain family 2 member D isoform 5; CLAX; LLT1; OCIL; Lectin like NK cell receptor; Lectin like transcript 1; Osteoclast inhibitory lectin; CLC2D_HUMAN; CLEC2D; CLEC2D protein; Lectin-like NK cell receptor; Lectin-like transcript 1; LLT-1; Osteoclast inhibitory lectin.
说 明 书0.1ml 0.2ml
研究领域免疫学 细胞表面分子 t-淋巴细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,
CLEC2D,CLEC2D蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:10-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量10kDa
细胞定位细胞膜 细胞外基质
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CLEC2D
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CLEC2D,CLEC2D蛋白抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified, but the full-length nature of every transcript has not been defined.

Function:
Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans.

Subunit:
Homodimer or heterodimer; disulfide-linked.

Subcellular Location:
Cell membrane; Single-pass type II membrane protein. Cell surface.
Isoform 2, 4: Endoplasmic reticulum.

Tissue Specificity:
Detected in fetal heart, brain, lung, chondrocytes, perichondrium and osteoblasts, and in adult splenocytes, thymocytes, lymph-node cells, osteoblasts, growth plate chondrocytes and skeltal muscle overlying the bone (at protein level). Ubiquitous. Detected in thymus, bone marrow, lung, gut, heart, skeletal muscle, ovary, spleen, ileum, liver and kidney.

Similarity:
Contains 1 C-type lectin domain.

Gene ID:
29121

CLEC2D,CLEC2D蛋白抗体Database links:
Entrez Gene: 29121 Human
Entrez Gene: 93694 Mouse
Entrez Gene: 113937 Rat
Omim: 605659 Human
SwissProt: Q9UHP7 Human
SwissProt: Q91V08 Mouse
SwissProt: Q925N7 Rat
Unigene: 268326 Human
Unigene: 197536 Mouse
Unigene: 22573 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.