CD83,CD83抗体

产品编号HZ-2519R
英文名称CD83
中文名称CD83抗体
别 名B cell activation 45kDa cell surface glycoprotein Ig superfamily; B cell activation protein; BL11; BL11 PEN; CD83 molecule; Cell surface protein HB15; HB15; MGC130312; MGC130313; Cell surface protein HB15; CD83_HUMAN.
说 明 书0.1ml 0.2ml
研究领域免疫学 细胞膜受体 t-淋巴细胞 b-淋巴细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
CD83,CD83抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量21kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CD83
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD83,CD83抗体PubMedPubMed
产品介绍background:
The CD83 antigen is a 186 amino acid single chain glycoprotein. This molecule is a member of the immunoglobulin superfamily and is composed of an extracellular V type immunoglobulin-like single domain, a transmembrane region, and a short, 40 amino acid cytoplasmic tail. CD83 antigen undergoes extensive post translational glycosylation, as the determined Mr is twice the predicted size of the core protein. However, CD83+ cells have a unique cell surface immunophenotype that does not correlate with that of T cells, B cells, NK cells, or cells of the myelomonocytic lineage. CD83+ cells coexpress the highest levels of MHC class II molecules, when compared with other leucocyte lineages. They also coexpress T cell markers (CD2, CD5), B cell markers (CD40, CD78), myeloid cell markers (CD13, CD33, CD36) and cytokine receptors, as well as other cell surface molecules.

Function:
May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation (By similarity).

Subunit:
Monomer.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Abundantly expressed in spleen and brain, but is also detected in most tissues analyzed.

Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Gene ID:
9308

CD83,CD83抗体Database links:
Entrez Gene: 9308 Human
Entrez Gene: 12522 Mouse
Entrez Gene: 361226 Rat
Omim: 604534 Human
SwissProt: Q01151 Human
SwissProt: O88324 Mouse
Unigene: 595133 Human
Unigene: 57175 Mouse
Unigene: 20096 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.