CACNB2,L-型电压依赖型钙通道β抗体
产品编号HZ-2996R
英文名称CACNB2
中文名称L-型电压依赖型钙通道β抗体
别 名Voltage-dependent L-type calcium channel subunit beta-2; CAB2; Cacnb2; Cacnlb2; VDCC-L Beta; Calcium channel voltage-dependent subunit beta 2; calcium channel, voltage-dependent, beta 2 subunit; calcium channel beta 2c subunit; calcium channel L-type beta 2 subunit; CACB2_HUMAN.
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 免疫学 神经生物学 通道蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit,
CACNB2,L-型电压依赖型钙通道β抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量74kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CACNB2 (621-670aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CACNB2,L-型电压依赖型钙通道β抗体PubMedPubMed
产品介绍background:
This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]
Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Subunit:
The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with RRAD. Interaction with RRAD regulates the trafficking of CACNA1C to the cell membrane.
Subcellular Location:
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
Similarity:
Belongs to the calcium channel beta subunit family.
Contains 1 SH3 domain.
Gene ID:
783
CACNB2,L-型电压依赖型钙通道β抗体Database links:
Entrez Gene: 783 Human
Entrez Gene: 12296 Mouse
Entrez Gene: 116600 Rat
Omim: 600003 Human
SwissProt: Q08289 Human
SwissProt: Q8CC27 Mouse
SwissProt: Q8VGC3 Rat
Unigene: 59093 Human
Unigene: 313930 Mouse
Unigene: 10739 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
电压依赖性钙通道(VDCC)是生物体内一大类钙通道蛋白,随着膜电位的改变而出现通道的开放、关闭和失活,调节细胞内Ca2+浓度,最终产生生物学效应.其亚型结构各异,VDCC β亚基具有调节其通道活性的作用,VDCC存在的普遍性决定了其作用的广泛性.在胰腺、心、脑、肾上腺、视网膜及神经等组织器官均有不同程度的分布.