CD84,CD84抗体

产品编号HZ-2520R
英文名称CD84
中文名称CD84抗体
别 名SLAM family member 5; Cell surface antigen MAX.3; eukocyte differentiation antigen; Hly9 beta; Leukocyte Antigen; Leukocyte differentiation antigen CD84; LY9B; Signaling lymphocytic activation molecule 5; SLAM family member 5; SLAMF5; SLAF5_MOUSE.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 细胞表面分子 t-淋巴细胞 b-淋巴细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,
CD84,CD84抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-300 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from mouse CD84
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD84,CD84抗体PubMedPubMed
产品介绍background:
This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

Function:
Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.

Subunit:
Homodimer; via its extracellular domain. Forms a head to tail dimer with a CD48 molecule from another cell. Interacts with SH2 domain-containing proteins SH2D1A/SAP and SH2D1B/hEAT-2. Interacts with tyrosine-protein phosphatases PTPN6 and PTPN11 via its phosphorylated cytoplasmic domain, and this interaction is blocked by SH2D1A.

CD84,CD84抗体Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Tissue Specificity:
Predominantly expressed in hematopoietic tissues such as lymph node, spleen, thymus, and bone marrow. Detected also in lung.

Post-translational modifications:
Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A/SAP is dependent of tyrosines phosphorylation of its cytoplasmic domain Phosphorylated on Tyr-280 and Tyr-300 following platelet aggregation.
N-glycosylated (By similarity).

Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like)

Gene ID:
12523

Database links:
Entrez Gene: 12523 Mouse
SwissProt: Q18PI6 Mouse
Unigene: 259115 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.