MCE .45UM WH GD 13MM 100/PK
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¿¹ÌåÀ´Ô´Rabbit
¿Ë¡ÀàÐÍPolyclonal
½»²æ·´Ó¦ Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
RAPGEF2,RapÄñàÑßʺËÜÕËá½»»»Òò×Ó2¿¹Ìå²úÆ·Ó¦ÓÃWB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 £¨Ê¯À¯ÇÐÆ¬Ðè×ö¿¹Ô­ÐÞ¸´£©
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
·Ö ×Ó Á¿167kDa
ϸ°û¶¨Î»Ï¸°û½¬ ϸ°ûĤ
ÐÔ ×´Lyophilized or Liquid
Ũ ¶È1mg/1ml
Ãâ Òß Ô­KLH conjugated synthetic peptide derived from human RAPGEF2 (501-600aa)
ÑÇ ÐÍIgG
´¿»¯·½·¨affinity purified by Protein A
´¢ ´æ Òº0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
±£´æÌõ¼þStore at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
RAPGEF2,RapÄñàÑßʺËÜÕËá½»»»Òò×Ó2¿¹ÌåPubMedPubMed
²úÆ·½éÉÜbackground:
SummaryMembers of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

Function:
Guanine nucleotide exchange factor (GEF) for Rap1A, Rap1B and Rap2B GTPases. Does not interact with cAMP or cGMP.

Subunit:
Interacts with MAGI2.

Subcellular Location:
Cell membrane (By similarity). Note=Associated with the synaptic plasma membrane

Tissue Specificity:
Highest expression levels in brain. Lower expression levels in heart, kidney, lung, and placenta.

Post-translational modifications:
Phosphorylation by PLK2 promotes its activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 1 cyclic nucleotide-binding domain.
Contains 1 N-terminal Ras-GEF domain.
Contains 1 PDZ (DHR) domain.
Contains 1 Ras-associating domain.
Contains 1 Ras-GEF domain.

Database links:
Entrez Gene: 9693 Human
Omim: 609530 Human
SwissProt: Q9Y4G8 Human
Unigene: 723853 Human

RAPGEF2,RapÄñàÑßʺËÜÕËá½»»»Òò×Ó2¿¹ÌåImportant Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ations.