SPON2,细胞外基质底物反应蛋白2抗体

产品编号HZ-11064R
英文名称SPON2
中文名称细胞外基质底物反应蛋白2抗体
别 名M spondin; Mindin; SPON 2; Differentially expressed in cancerous and non-cancerous lung cells 1; DIL 1; DIL-1; DIL1; M spondin; Mindin; Spon2; SPON2_HUMAN; Spondin 2; Spondin-2.
说 明 书0.1ml 0.2ml
研究领域神经生物学 信号转导 细胞粘附分子 细胞外基质
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Horse,
SPON2,细胞外基质底物反应蛋白2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量33kDa
细胞定位细胞外基质 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SPON2_HUMAN
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
SPON2,细胞外基质底物反应蛋白2抗体
PubMedPubMed
产品介绍background:
The Thrombospondin proteins, Thrombospondins 1-4 and Thrombospondin 5 (also designated COMP), compose a family of glycoproteins that are involved in cell-to-cell and cell-to-matrix signaling. These extracellular, cell-surface proteins form complexes of both homo- and heteromultimers. Spondin-2, or Mindin, is also designated DIL-1 for its differential expression in cancerous and non-cancerous lung cells. Full-length SPON2 cDNA encodes a 331 amino acid protein with a domain arrangement similar to zebrafish F-Spondin and Mindin-1/Mindin-2: an FS1 domain, an FS2 domain, a hydrophobic signal sequence in the N-terminus and a Thrombospondin type I repeat. Immunoblot analysis demonstrates expression of dimers and oligomers in a concentration-dependent manner under nonreducing conditions.

Function:
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).

Subunit:
Monomer. Interacts with integrin.

Subcellular Location:
Secreted; extracellular space; extracellular matrix.

SPON2,细胞外基质底物反应蛋白2抗体Tissue Specificity:
Expressed in normal lung tissue but not in lung carcinoma cell lines.

Similarity:
Contains 1 spondin domain. Contains 1 TSP type-1 domain.

Database links:
Entrez Gene: 10417 Human
Entrez Gene: 100689 Mouse
Entrez Gene: 171569 Rat
Omim: 605918 Human
SwissProt: Q9BUD6 Human
SwissProt: Q8BMS2 Mouse
SwissProt: Q9WV75 Rat
Unigene: 302963 Human
Unigene: 635350 Human
Unigene: 34694 Mouse
Unigene: 6699 Rat

SPON2,细胞外基质底物反应蛋白2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.