Junctophilin 4.连接蛋白JPH4抗体

产品编号HZ-11084R
英文名称Junctophilin 4
中文名称连接蛋白JPH4抗体
别 名JP-4; Jph4; JPH4_HUMAN; JPHL1; Junctophilin4; Junctophilin like 1 protein; Junctophilin-4; Junctophilin-like 1 protein; KIAA1831.
说 明 书0.1ml 0.2ml
研究领域发育生物学 神经生物学 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse,
Junctophilin 4.连接蛋白JPH4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量66kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Junctophilin 4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Junctophilin 4.连接蛋白JPH4抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the junctophilin family of transmembrane proteins that are involved in the formation of the junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum in excitable cells. The encoded protein contains a conserved N-terminal repeat region called the membrane occupation and recognition nexus sequence that is found in other members of the junctophilin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

Function:
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity).

Subcellular Location:
Cell membrane; Peripheral membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity). Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity).

Similarity:
Belongs to the junctophilin family.
Contains 8 MORN repeats.

Database links:
Entrez Gene: 84502 Human
Entrez Gene: 319984 Mouse
Entrez Gene: 445271 Rat
SwissProt: Q96JJ6 Human
SwissProt: Q80WT0 Mouse
SwissProt: Q69FB3 Rat
Unigene: 597841 Human
Unigene: 19047 Mouse
Unigene: 163297 Rat

Junctophilin 4.连接蛋白JPH4抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.