Osteocalcin,骨钙蛋白/骨钙素抗体

产品编号HZ-4917R
英文名称Osteocalcin
中文名称骨钙蛋白/骨钙素抗体
别 名Osteocalcin Propeptide; Osteocalcin; Osteocalcin precursor; Gamma-carboxyglutamic acid-containing protein; Bone Gla-protein; BGLAP; Bone gamma carboxyglutamate protein; BGLAP; BGP; Bone gamma carboxyglutamate gla protein osteocalcin; Bone gamma carboxyglutamate protein; Bone Gla protein; Gamma carboxyglutamic acid containing protein; OC; PMF1; OSTCN_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 干细胞 细胞外基质
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse,
Osteocalcin,骨钙蛋白/骨钙素抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量11kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Osteocalcin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Osteocalcin,骨钙蛋白/骨钙素抗体PubMedPubMed
产品介绍background:
Osteocalcin belongs to the osteocalcin/matrix Gla protein family and constitutes 1 to 2% of the total bone protein. It is a 49 amino acid single chain vitamin K dependent protein, made by osteoblasts, and is a major component of the noncollagenous bone matrix. Post translational modification by a vitamin K dependent carboxylase produces three gamma carboxyglutamic acid residues at positions 17, 21 and 24, giving it a high affinity for calcium. It also binds strongly to apatite.

Function:
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Subcellular Location:
Secreted.

Post-translational modifications:
Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.

Similarity:
Belongs to the osteocalcin/matrix Gla protein family.
Contains 1 Gla (gamma-carboxy-glutamate) domain.

Gene ID:
632

Database links:
Entrez Gene: 281646 Cow
Entrez Gene: 632 Human
Entrez Gene: 397530 Pig
Entrez Gene: 25295 Rat
Omim: 112260 Human
SwissProt: P02820 Cow
SwissProt: P02818 Human
SwissProt: Q8HYY9 Pig
SwissProt: P04640 Rat
Unigene: 654541 Human
Unigene: 9722 Rat

Osteocalcin,骨钙蛋白/骨钙素抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.