SLC40A1,细胞膜铁转运蛋白FP1抗体

产品编号HZ-4906R
英文名称SLC40A1
中文名称细胞膜铁转运蛋白FP1抗体
别 名Ferroportin 1; Ferroportin-1; FPN1; HFE4; IREG1; Iron regulated transporter 1; Iron-regulated transporter 1; MTP1; S40A1_HUMAN; SLC40A1; Solute carrier family 40 member 1; MST079; MSTP079; MTP1; SLC11A3.
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 信号转导 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Rabbit,
SLC40A1,细胞膜铁转运蛋白FP1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量63kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SLC40A1/FPN1 (365-405aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
SLC40A1,细胞膜铁转运蛋白FP1抗体PubMedPubMed
产品介绍background:
SLC40A1 may be involved in iron export from duodenal epithelial cells and also in transfer of iron between maternal and fetal circulation. It mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4, an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin.

Function:
May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).

Subunit:
Belongs to the S1LC40A transporter family.

Subcellular Location:
Cell membrane. Localized to the basolateral membrane of polarized epithelial cells.

Tissue Specificity:
Expressed in placenta, intestine, muscle and spleen.

SLC40A1,细胞膜铁转运蛋白FP1抗体DISEASE:
Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4) [MIM:606069]. HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation.

Similarity:
Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.

Database links:
Entrez Gene: 30061 Human
Entrez Gene: 53945 Mouse
Entrez Gene: 170840 Rat
Omim: 604653 Human
SwissProt: Q9NP59 Human
SwissProt: Q9JHI9 Mouse
SwissProt: Q923U9 Rat
Unigene: 643005 Human
Unigene: 28756 Mouse
Unigene: 15324 Rat

SLC40A1,细胞膜铁转运蛋白FP1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片

Tissue/cell: human placenta tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;  Incubation: Anti-SLC40A1/FPN1 Polyclonal Antibody, Unconjugated(HZ-4906R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining