NAT8B,N-乙酰转移酶8B抗体

产品编号HZ-11592R
英文名称NAT8B
中文名称N-乙酰转移酶8B抗体
别 名Camello like protein 2; Camello-like protein 2; CML2; Hcml2; N acetyltransferase 8B; NAT8B; NAT8B_HUMAN; NAT8BP; Probable N acetyltransferase 8B; Probable N-acetyltransferase 8B.
说 明 书0.1ml 0.2ml
研究领域肿瘤 发育生物学 细胞周期蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Horse, Sheep,
NAT8B,N-乙酰转移酶8B抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量25kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human NAT8B
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
NAT8B,N-乙酰转移酶8B抗体PubMedPubMed
产品介绍background:
Acetyltransferases and deacetylases are protein groups most often associated with oncogenesis and cell cycle regulation. NAT-8B (N-acetyltransferase 8B), also known as CML2 (camello-like protein 2), is a 227 amino acid single-pass membrane protein that is implicated in gastrulation regulation. A member of the camello family, NAT-8B contains one N-acetyltransferase domain and is encoded by a gene that maps to human chromosome 2p13.2. The NAT-8B gene is susceptible to a nonsense mutation at Serine 16, which leads to a stop codon and subsequently, a non-functional protein that is truncated in length. Similarly, a nonsense mutation at Glutamine 168 is thought to lead to a non-functional protein, as it causes the N-acetyltransferase to become disrupted. Human chromosome 2 consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome.

Function:
May play a role in regulation of gastrulation.

Subcellular Location:
Membrane; Single-pass membrane protein

Similarity:
Belongs to the camello family.
Contains 1 N-acetyltransferase domain.

Database links:
Entrez Gene: 51471 Human
NCBI: NP_057431 Human
Omim: 608190 Human
SwissProt: Q9UHF3 Human
Unigene: 728429 Human

NAT8B,N-乙酰转移酶8B抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.