BACE2,β淀粉样前体蛋白裂解酶2抗体

产品编号HZ-11680R
英文名称BACE2
中文名称β淀粉样前体蛋白裂解酶2抗体
别 名ALP 56; ALP-56; ALP56; ALP56; Asp 1; ASP1; ASP1; ASP21; Aspartic Like Protease 56kDa; Aspartic Like Protease 56kDa; Aspartic-like protease 56 kDa; Aspartyl protease 1; Aspartyl protease 1; BACE 2; BACE 2; Bace2; BACE2_HUMAN; Beta Secretase 2; Beta Secretase 2; Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2; Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2; Beta-secretase 2; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Down region aspartic protease; Down region aspartic protease; Downs Syndrome Region Aspartic Protease; Downs Syndrome Region Aspartic Protease; DRAP; Memapsin 1; Memapsin1; Memapsin-1; Membrane associated aspartic protease 1; Membrane-associated aspartic protease 1; Theta-secretase.
说 明 书0.1ml 0.2ml
BACE2,β淀粉样前体蛋白裂解酶2抗体研究领域细胞生物 神经生物学 Alzheimer's
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat, Dog,
产品应用IHC-P=1:100-500 IHC-F=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量50kDa
细胞定位细胞浆 细胞膜 细胞外基质
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human BACE2 (101-200aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
BACE2,β淀粉样前体蛋白裂解酶2抗体PubMedPubMed
产品介绍background:
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

Function:
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.

Subunit:
Monomer. Interacts ith RTN3 and RTN4.

Subcellular Location:
Membrane. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.

Tissue Specificity:
Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.

BACE2,β淀粉样前体蛋白裂解酶2抗体Post-translational modifications:
Undergoes autoproteolytic cleavage.
Glycosylated.

Similarity:
Belongs to the peptidase A1 family.

Gene ID:
25825

Database links:
Entrez Gene: 25825 Human
Entrez Gene: 56175 Mouse
Entrez Gene: 288227 Rat
Omim: 605668 Human
SwissProt: Q9Y5Z0 Human
SwissProt: Q9JL18 Mouse
SwissProt: Q6IE75 Rat
Unigene: 529408 Human
Unigene: 97885 Mouse
Unigene: 38581 Rat