APOL4,载脂蛋白L4抗体

产品编号HZ-12499R
英文名称APOL4
中文名称载脂蛋白L4抗体
别 名APOL IV; ApoL-IV; APOL4; APOL4_HUMAN; Apolipoprotein L IV; Apolipoprotein L-IV; Apolipoprotein L4; APOLIV; CTA 212A2.2; OTTHUMP00000028937.
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,
APOL4,载脂蛋白L4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量37kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human APOL4/Apolipoprotein L4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
APOL4,载脂蛋白L4抗体PubMedPubMed
产品介绍background:
The apolipoprotein L gene family maps to a region on chromosome 22 and encodes six highly homologous proteins designated apoL-I, apoL-II, apoL-III, apoL-IV, apoL-V and apoL-VI, all of which function as components of plasma lipoproteins. ApoL-IV (apolipoprotein L-IV), also known as APOL4, is a 351 amino acid protein that exists as multiple alternatively spliced isoforms, one of which is secreted. Expressed in spleen, placenta, spinal cord, uterus, testis and trachea, apoL-IV is thought to play a role in lipid exchange and transport throughout the body and may be involved in reverse cholesterol transport, specifically from peripheral cells to the liver. Overexpression of apoL-IV is associated with schizophrenia, suggesting that apoL-IV may play a role in the pathogenesis of neural disorders.

Function:
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.

Subcellular Location:
Secreted.

Tissue Specificity:
Widely expressed; the highest levels are in spinal cord, placenta, adrenal gland; also detected in spleen, bone marrow, uterus, trachea, mammary gland and testis; levels are low in brain, heart and pancreas.

Similarity:
Belongs to the apolipoprotein L family.

Database links:
Entrez Gene: 80832 Human
Omim: 607254 Human
SwissProt: Q9BPW4 Human
Unigene: 726733 Human

APOL4,载脂蛋白L4抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.