KLHDC5,kelch样蛋白5抗体

产品编号HZ-7806R
英文名称KLHDC5
中文名称kelch样蛋白5抗体
别 名Ctb9; kelch domain containing 5; KLH42_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 细胞周期蛋白 细胞分化
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
KLHDC5,kelch样蛋白5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human KLHDC5
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
KLHDC5,kelch样蛋白5抗体PubMedPubMed
产品介绍background:
KLHDC5 contains 1 BTB (POZ) domain and 6 Kelch repeats. It is phosphorylated upon DNA damage, possibly by ATM or ATR. The exact function of KLHDC5 is currently unknown.

Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.

Subunit:
Component of the BCR(KLHL42) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL42. Interacts (via the BTB domain) with CUL3. Interacts (via the kelch domains) with KATNA1.

KLHDC5,kelch样蛋白5抗体Similarity:
Contains 1 BTB (POZ) domain.

Database links:

UniProtKB/Swiss-Prot: Q9P2K6.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.