FNDC5,Ⅲ型纤维连接蛋白域蛋白2/5抗体

产品编号HZ-8486R
英文名称FNDC5
中文名称Ⅲ型纤维连接蛋白域蛋白2/5抗体
别 名FNDC5; Fibronectin type III domain containing 5; Fibronectin type III domain-containing protein 5; Fibronectin type III repeat containing protein 2; Fibronectin type III repeat-containing protein 2; FNDC 5; Fndc5; FNDC5_HUMAN; FRCP2; Irisin.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 G蛋白信号
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Rabbit,
FNDC5,Ⅲ型纤维连接蛋白域蛋白2/5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量12/20kDa
细胞定位细胞浆 细胞膜 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human FNDC5 Irisin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FNDC5,Ⅲ型纤维连接蛋白域蛋白2/5抗体PubMedPubMed
产品介绍background:
This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].

Function:
Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA (By similarity).

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein (By similarity). Note=Imported in peroxisomes through the PEX5 receptor pathway (By similarity).
Irisin: Secreted. Note=Detected in the blood of individuals subjected to endurance exercise.

Post-translational modifications:
The extracellular domain is cleaved and released from the cell membrane.
N-Glycosylated.

Similarity:
Contains 1 fibronectin type-III domain.

Gene ID:
252995

FNDC5,Ⅲ型纤维连接蛋白域蛋白2/5抗体Database links:
Entrez Gene: 252995 Human
Entrez Gene: 384061 Mouse
Entrez Gene: 260327 Rat
Omim: 611906 Human
SwissProt: Q8NAU1 Human
SwissProt: Q8K4Z2 Mouse
SwissProt: Q8K3V5 Rat
Unigene: 524234 Human
Unigene: 44075 Mouse
Unigene: 18757 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.