CIP29,细胞因子诱导蛋白29kDa抗体

产品编号HZ-13957R
英文名称CIP29
中文名称细胞因子诱导蛋白29kDa抗体
别 名Cytokine induced protein of 29 kDa; Cytokine-induced protein of 29 kDa; HCC 1; HCC1; HSPC316; Nuclear protein Hcc 1; Nuclear protein Hcc-1; Proliferation associated cytokine inducible protein CIP29; Proliferation-associated cytokine-inducible protein CIP29; SAP domain-containing ribonucleoprotein; SARNP; SARNP_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 信号转导 细胞凋亡 细胞周期蛋白 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse,
CIP29,细胞因子诱导蛋白29kDa抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量24kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CIP29
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CIP29,细胞因子诱导蛋白29kDa抗体PubMedPubMed
产品介绍background:
CIP29 is a 210 amino acid nuclear protein whose expression is upregulated by erythropoietin. Induction of CIP2 expression is associated with cell cycle progression and apoptosis. This transcription factor binds both single stranded (ss) and double stranded (ds) DNA, though it has higher affinity for ssDNA. CIP29 is expressed at low levels in pancreas, spleen, testis, liver, kidney, heart and thymus, and is found to be expressed at higher levels in pancreatic adenocarcinoma and hepatocellular carcinoma. A translocation t(11;12)(q23;q13) in acute myelomonocytic leukemia results in the coding region of CIP29 gene fused to exon 9 of the MLL gene, which encodes for a protein with the N-terminal SAP domain and two C-terminal nuclear localization signals of CIP29 and N-termial AT hooks and central DNA methyltransferase homology region of MLL.

Function:
Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis.

Subcellular Location:
Nucleus.

Tissue Specificity:
Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma.

DISEASE:

CIP29,细胞因子诱导蛋白29kDa抗体Similarity:
Contains 1 SAP domain.

Gene ID:
84324

Database links:
Entrez Gene: 84324 Human
Entrez Gene: 732539 Cow
Entrez Gene: 66118 Mouse
Entrez Gene: 362819 Rat
Omim: 610049 Human
SwissProt: P82979 Human
SwissProt: Q9D1J3 Mouse
SwissProt: Q498U4 Rat
Unigene: 505676 Human
Unigene: 351579 Mouse
Unigene: 1506 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.