CCN1,富半胱氨酸肝素结合蛋白61抗体

产品编号HZ-1290R
英文名称CCN1
中文名称富半胱氨酸肝素结合蛋白61抗体
别 名Cyr61; IGFBP10; cysteine rich protein 61; 3CH61; CCN 1; CCN1; CYR 61; CYR61; CYR61 protein; CYR61 protein precursor; Cysteine rich angiogenic inducer 61; Cysteine rich heparin binding protein 61; GIG 1; GIG1; GIG1; Igfbp 10; IGFBP10; *** like growth factor binding protein 10; Protein CYR61; Protein GIG1; AI325051; cysteine rich 61; CYR61_HUMAN .
说 明 书0.1ml 0.2ml
研究领域肿瘤
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
CCN1,富半胱氨酸肝素结合蛋白61抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Cyr61
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CCN1,富半胱氨酸肝素结合蛋白61抗体PubMedPubMed
产品介绍background:
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

Function:
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Subcellular Location:
Secreted.

Similarity:
Belongs to the CCN family.
Contains 1 CTCK (C-terminal cystine knot-like) domain.
Contains 1 IGFBP N-terminal domain.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.

CCN1,富半胱氨酸肝素结合蛋白61抗体Gene ID:
3491

Database links:
Entrez Gene: 3491 Human
Entrez Gene: 16007 Mouse
Entrez Gene: 83476 Rat
Entrez Gene: 508941 Cow
Omim: 602369 Human
SwissProt: O00622 Human
SwissProt: P18406 Mouse
SwissProt: Q9ES72 Rat
Unigene: 8867 Human
Unigene: 1231 Mouse
Unigene: 22129 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

高半胱氨酸蛋白61是富含半胱氨酸的分泌性肝素连接蛋白，是CCN家族成员之一，属于生长因子诱导的即刻早期基因，有明显的促有丝分裂和趋化活性作用，有诱导成纤维细胞增殖和分泌细胞外基质等功能，可促进细胞增殖、迁移、黏附、分化和细胞外基质（ECM）合成的作用，在新生血管及肿瘤形成过程中起着重要作用。