Claudin 5,紧密连接蛋白5抗体

产品编号HZ-10296R
英文名称Claudin 5
中文名称紧密连接蛋白5抗体
别 名AWAL; BEC 1; BEC1; Claudin 5 (transmembrane protein deleted in velocardiofacial syndrome); Claudin5; Claudin-5;CLDN 5; CLDN5; CPETR L1; CPETRL 1; CPETRL1; TMDVCF; TMVCF; Transmembrane protein deleted in VCFS; Transmembrane protein deleted in velocardiofacial syndrome; Androgen withdrawal and apoptosis induced protein RVP1 like; CLD5_HUMAN.
说 明 书0.1ml 0.2ml
研究领域信号转导 细胞粘附分子 细胞骨架
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
Claudin 5,紧密连接蛋白5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量23kDa
细胞定位细胞膜 细胞外基质
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Claudin 5
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Claudin 5,紧密连接蛋白5抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008]

Function:
Plays a major role in tight junction-specific obliteration of the intercellular space.

Subunit:
Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ.

Subcellular Location:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.

Similarity:
Belongs to the claudin family.

Gene ID:
7122

Database links:
Entrez Gene: 7122 Human
Entrez Gene: 12741 Mouse
Omim: 602101 Human
SwissProt: Q2HJ22 Cow
SwissProt: O00501 Human
SwissProt: O54942 Mouse
Unigene: 505337 Human
Unigene: 22768 Mouse

Claudin 5,紧密连接蛋白5抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片	Protein: mouse lung lysates; Primary: Anti-Claudin 5 (HZ-10296R) at 1:300;  Secondary: HRP conjugated Goat-Anti-Rabbit IgG(HZ-0295G-HRP) at 1: 5000;  ECL excitated the fluorescence;  Predicted band size :23 kD Observed band size :23/33/70 kD