CPLA2 beta,胞浆型***脂酶A2抗体

产品编号HZ-3780R
英文名称CPLA2 beta
中文名称胞浆型***脂酶A2抗体
别 名CPLA2 beta; Cytosolic phospholipase A2 beta; DKFZp686N12131; FLJ17693; FLJ42498; FLJ53173; PA24B_HUMAN; HsT16992; OTTHUMP00000201605; OTTHUMP00000210673; Phospholipase A2 group IVB; Phospholipase A2, group IVB (cytosolic); PLA2G4B.
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Horse,
CPLA2 beta,胞浆型***脂酶A2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量88kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CPLA2 beta
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CPLA2 beta,胞浆型***脂酶A2抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains.

Function:
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine.

Subcellular Location:
Cytoplasm, cytosol.
Isoform 3: Mitochondrion membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Note=Translocates to membrane vesicles in a calcium-dependent fashion.

Tissue Specificity:
Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas. Isoform 3 is widely expressed.

Similarity:
Contains 1 C2 domain.
Contains 1 PLA2c domain.

CPLA2 beta,胞浆型***脂酶A2抗体Database links:
UniProtKB/Swiss-Prot: P0C869.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.