Cullin 1,Cullin1抗体

产品编号HZ-4208R
英文名称Cullin 1
中文名称Cullin1抗体
别 名Cullin-1; CUL 1; CUL1; Cullin1; MGC149834; MGC149835.
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 信号转导 细胞周期蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Cow, Rabbit,
Cullin 1,Cullin1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量85kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Cullin 1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Cullin 1,Cullin1抗体PubMedPubMed
产品介绍background:
Cullin 1 may be involved in the degradation of positive cell cycle regulators (for example G1 cyclins in yeast). Human cullin 1 forms a complex with Skp1 and the F box protein Skp2, which is thought to play a role in the ubiquitination of G1 regulatory proteins, as its homolog does in yeast.

Tissue Specificity:
Expressed in lung fibroblasts.

Post-translational modifications:
Neddylated; which enhances the ubiquitination activity of SCF. Deneddylated via its interaction with the COP9 signalosome (CSN) complex. Deneddylated by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of the viral genome.

Similarity:
Belongs to the cullin family.

Cullin 1,Cullin1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.