CEBP Beta,转录调节因子C/EBP β抗体

产品编号HZ-1396R
英文名称CEBP Beta
中文名称转录调节因子C/EBP β抗体
别 名CEBP-beta; CLEBP beta; CCAAT Enhancer Binding Protein beta; AGP/EBP; C EBP beta; C/EBP related protein 2; CEBPB; CRP2; IL 6DBP; IL6DBP; Interleukin 6 dependent binding protein; LAP; Liver enriched transcriptional activator; NF IL6; NFIL6; Nuclear factor NF IL6; SF B; SFB; Silencer factor B; TCF5; Transcription factor 5; C/EBP beta; CCAAT/enhancer-binding protein beta; CEBPB_HUMAN; Liver activator protein; Liver enriched transcriptional activator; Nuclear factor NF IL6; Nuclear factor NF-IL6; TCF-5.
说 明 书0.1ml 0.2ml
研究领域肿瘤 染色质和核信号 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Sheep,
CEBP Beta,转录调节因子C/EBP β抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量36kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CEBP Beta
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CEBP Beta,转录调节因子C/EBP β抗体PubMedPubMed
产品介绍background:
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. [provided by RefSeq].

Function:
Involved in interleukin-6 signal transduction, including the transcriptional activation of acute-phase genes. Functions in brown adipose tissue (BAT) differentiation.

Subunit:
Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha and gamma. Interacts with TRIM28 and PTGES2. Interacts with PRDM16. Interacts with CCDC85B.

Subcellular Location:
Nucleus.

Post-translational modifications:
Sumoylated by polymeric chains of SUMO2 or SUMO3.

CEBP Beta,转录调节因子C/EBP β抗体Similarity:
Belongs to the bZIP family. C/EBP subfamily.
Contains 1 bZIP domain.

Gene ID:
1051

Database links:
Entrez Gene: 1051 Human
Entrez Gene: 12608 Mouse
Entrez Gene: 24253 Rat
Omim: 189965 Human
SwissProt: P17676 Human
SwissProt: P28033 Mouse
SwissProt: P21272 Rat
Unigene: 517106 Human
Unigene: 719041 Human
Unigene: 720603 Human
Unigene: 439656 Mouse
Unigene: 6479 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

转录调节因子（Transcriptin Regulators）