CD39L4,原癌基因CD39样蛋白4/ENTPD5抗体

产品编号HZ-6526R
英文名称CD39L4
中文名称原癌基因CD39样蛋白4/ENTPD5抗体
别 名CD39 like 4; AI196558; AI987697; CD39 antigen like 4; CD39 antigen-like 4; CD39 like 4; CD39L4; Ectonucleoside triphosphate diphosphohydrolase 5; ENTP5_HUMAN; Entpd5; ER UDPase; ER-UDPase; GDPase ENTPD5; Guanosine-diphosphatase ENTPD5; MGC163357; MGC163359; mNTPase; NTPDase 5; Nucleoside diphosphatase; PCPH; Pcph proto oncogene protein; Proto oncogene CPH; UDPase ENTPD5; Uridine-diphosphatase ENTPD5
说 明 书0.1ml 0.2ml
研究领域肿瘤 染色质和核信号 信号转导 肿瘤细胞生物标志物 新陈代谢 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep,
CD39L4,原癌基因CD39样蛋白4/ENTPD5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量47kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ENTPD5/CD39L4 (331-380aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD39L4,原癌基因CD39样蛋白4/ENTPD5抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases.

Function:
Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. Also hydrolyzes GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling

Subcellular Location:
Endoplasmic reticulum membrane, Single-pass type II membrane protein

Tissue Specificity:
Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues.

Post-translational modifications:
N-glycosylated; high-mannose type

Similarity:
Belongs to the GDA1/CD39 NTPase family.

Database links:
Entrez Gene: 957 Human
Entrez Gene: 12499 Mouse
Entrez Gene: 314312 Rat
Omim: 603162 Human
SwissProt: O75356 Human
SwissProt: Q9WUZ9 Mouse
SwissProt: Q6P6S9 Rat
Unigene: 720540 Human
Unigene: 10211 Mouse
Unigene: 63533 Rat

CD39L4,原癌基因CD39样蛋白4/ENTPD5抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.