DULLARD,DULLARD蛋白抗体

产品编号HZ-11828R
英文名称DULLARD
中文名称DULLARD蛋白抗体
别 名Dullard homolog; HSA 011916; NET 56 antibodySerine threonine protein phosphatase dullard; CNEP1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域神经生物学 信号转导 激酶和***酸酶 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Horse,
DULLARD,DULLARD蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量28kDa
细胞定位细胞核 细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DULLARD
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DULLARD,DULLARD蛋白抗体PubMedPubMed
产品介绍background:
In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. Dullard, also known as NET56, is a 244 amino acid single-pass membrane protein that localizes to both the nucleus and the endoplasmic reticulum and contains one FCP1 homology domain. Functioning as a serine/threonine phosphatase, Dullard catalyses the dephosphorylation of target proteins and is thought to be required for proper nuclear membrane morphology. Human Dullard shares 92% sequence identity with its zebrafish counterpart, suggesting a conserved role between species.

Function:
DULLARD is a serine/threonine phosphatase which may be required for proper nuclear membrane morphology. It is involved in LPIN1 dephosphorylation and may antagonize BMP signaling.

Subunit:
Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nuclear membrane; Single-pass membrane protein.

Tissue Specificity:
Muscle specific with lower expression in other metabolic tissues.

Similarity:
Belongs to the dullard family.
Contains 1 FCP1 homology domain.

DULLARD,DULLARD蛋白抗体Database links:
UniProtKB/Swiss-Prot: O95476.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.