GPR183,G蛋白偶联受体183抗体

产品编号HZ-14497R
英文名称GPR183
中文名称G蛋白偶联受体183抗体
别 名ebi 2; EBI2; EBV induced G protein coupled receptor 2; EBV-induced G-protein coupled receptor 2; ebv-induced gene 2; Epstein-Barr virus-induced gene 2; Epstein Barr virus induced gene 2; epstein-barr virus induced gene 2; Epstein-Barr virus-induced G-protein coupled receptor 2; G protein-coupled receptor 183; G-protein coupled receptor 183; GP183_HUMAN; gpr183; Lymphocyte specific G protein coupled receptor.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 细菌及病毒 G蛋白偶联受体 G蛋白信号 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
GPR183,G蛋白偶联受体183抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量41kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human EBV Induced Gene 2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
GPR183,G蛋白偶联受体183抗体PubMedPubMed
产品介绍background:
Epstein-Barr virus-induced gene 2 is a 357 amino acid multi pass membrane protein. It is expressed in B-lymphocytes and lymphoid tissues and may function in the modulation of the immune system. Out of the nine genes that are induced by the Epstein-Barr virus, Ebi2 exhibits the highest levels of up-regulation. Ebi2 is a G-protein coupled receptor that signals through the G-protein G錳. Ebi2 contains seven hydrophobic transmembrane regions and a putative N-linked glycosylation site at its extracellular N-terminus. Ebi2 is believed to be involved in regulating the effects of the Epstein-Barr virus on B-lymphocytes. In addition, Ebi2 may play a role mediating normal lymphocyte functions.

Function:
Orphan receptor that plays a central role during humoral immunity. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha.

Subunit:

Subcellular Location:
Cell membrane.

GPR183,G蛋白偶联受体183抗体Tissue Specificity:
Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes. Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Gene ID:
1880

Database links:
Entrez Gene: 1880 Human
Entrez Gene: 769212 Chicken
Entrez Gene: 540287 Cow
Entrez Gene: 100050745 Horse
Entrez Gene: 100388743 Marmoset (common)
Entrez Gene: 321019 Mouse
Entrez Gene: 679975 Rat
Omim: 605741 Human
SwissProt: Q1RMI1 Cow
SwissProt: P32249 Human
SwissProt: Q3U6B2 Mouse
SwissProt: D4A7K7 Rat
Unigene: 784 Human
Unigene: 265618 Mouse
Unigene: 179130 Rat

GPR183,G蛋白偶联受体183抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.