human Fibrinogen,人纤维蛋白原抗体

产品编号HZ-1240R
英文名称human Fibrinogen
中文名称人纤维蛋白原抗体
别 名FGA; FGA protein; FGB; FGG; Fib2; Fibrin alpha chain ;Fibrinogen A alpha polypeptide; Fibrinogen A alpha polypeptide chain; Fibrinogen alpha chain; Fibrinogen B alpha polypeptide; Fibrinogen beta chain; Fibrinogen G alpha polypeptide; Fibrinogen gamma chain; MGC104327; MGC119422; MGC119423; MGC119425; MGC120405; FIBA_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 信号转导 细胞骨架
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
human Fibrinogen,人纤维蛋白原抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量95/340kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原Fibrinogen from human plasma
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
human Fibrinogen,人纤维蛋白原抗体PubMedPubMed
产品介绍background:
Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.

Function:
Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.

Subcellular Location:
Secreted.

Tissue Specificity:
Plasma.

human Fibrinogen,人纤维蛋白原抗体Post-translational modifications:
The alpha chain is not glycosylated.
Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers. About one-third of the alpha chains in the molecules in blood were found to be phosphorylated.
Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Phosphorylation sites are present in the extracellular medium.

DISEASE:

Similarity:
Contains 1 fibrinogen C-terminal domain.

Gene ID:
2243

Database links:
Entrez Gene: 2243 Human
Entrez Gene: 2244 Human
Entrez Gene: 2266 Human
Entrez Gene: 110135 Mouse
Entrez Gene: 14161 Mouse
Entrez Gene: 99571 Mouse
Omim: 134820 Human
Omim: 134830 Human
Omim: 134850 Human
SwissProt: P02671 Human
SwissProt: P02675 Human
SwissProt: P02679 Human
SwissProt: Q8K0E8 Mouse
SwissProt: Q8VCM7 Mouse
Unigene: 300774 Human
Unigene: 351593 Human
Unigene: 727584 Human
Unigene: 16422 Mouse
Unigene: 30063 Mouse
Unigene: 88793 Mouse

human Fibrinogen,人纤维蛋白原抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.