GMCL1L,生殖细胞样蛋白1样蛋白抗体

产品编号HZ-6892R
英文名称GMCL1L
中文名称生殖细胞样蛋白1样蛋白抗体
别 名GCL; Germ cell less homolog 1 (Drosophila) like; Germ cell less protein like 1 like; GMCL 2; GMCL2; GMCLL_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 发育生物学 细胞周期蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
GMCL1L,生殖细胞样蛋白1样蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量60kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human GMCL1L
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
GMCL1L,生殖细胞样蛋白1样蛋白抗体PubMedPubMed
产品介绍background:
GMCL1L has a possible function in spermatogenesis. It enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport. GMCL1L is also a probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Function:
Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. [PATHWAY] Protein modification; protein ubiquitination.

Subunit:
Interacts with TMPO-Beta, TSG101 and TFDP2. Interacts with EMD (By similarity). Interacts with CUL3.

Subcellular Location:
Nucleus matrix (By similarity).

GMCL1L,生殖细胞样蛋白1样蛋白抗体Similarity:
Contains 1 BTB (POZ) domain.

Database links:
UniProtKB/Swiss-Prot: Q8NEA9.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片	Western blot analysis of extracts from Placenta using GMCL1L