BTR1,钙粘蛋白相关蛋白受体BTR1抗体

产品编号HZ-13714R
英文名称BTR1
中文名称钙粘蛋白相关蛋白受体BTR1抗体
别 名BT R1; BTR1; NaBC1; SLC4A11; sodium bicarbonate transporter-like protein 11; solute carrier family 4 member 11; S4A11_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
BTR1,钙粘蛋白相关蛋白受体BTR1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量100kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human BTR1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
BTR1,钙粘蛋白相关蛋白受体BTR1抗体PubMedPubMed
产品介绍background:
BtR1 is a cadherin receptor from the tobacco hornworm Manduca sexta.

Function:
Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter.

Subunit:
Homodimer.

Subcellular Location:
Cell membrane. Membrane; Multi-pass membrane protein.

Tissue Specificity:
Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes.

Post-translational modifications:
Glycosylated.

DISEASE:
Corneal dystrophy and perceptive deafness (CDPD) [MIM:217400]: An ocular disease characterized by the association of corneal clouding with progressive perceptive hearing loss. Note=The disease is caused by mutations affecting the gene represented in this entry.
Corneal dystrophy, endothelial 2, autosomal recessive (CHED2) [MIM:217700]: A congenital corneal dystrophy characterized by thickening and opacification of the cornea, altered morphology of the endothelium, and secretion of an abnormal collagenous layer at the Descemet membrane. Note=The disease is caused by mutations affecting the gene represented in this entry.
Corneal dystrophy, Fuchs endothelial, 4 (FECD4) [MIM:613268]: A corneal disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition. Note=The disease is caused by mutations affecting the gene represented in this entry.

BTR1,钙粘蛋白相关蛋白受体BTR1抗体Similarity:
Belongs to the anion exchanger (TC 2.A.31) family.

Gene ID:
83959

Database links:
Entrez Gene: 83959 Human
Entrez Gene: 532407 Cow
Entrez Gene: 269356 Mouse
Entrez Gene: 311423 Rat
Omim: 610206 Human
SwissProt: Q8NBS3 Human
SwissProt: A2AJN7 Mouse
Unigene: 105607 Human
Unigene: 441391 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片

Tissue/cell: human kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;  Incubation: Anti-BTR1 Polyclonal Antibody, Unconjugated(HZ-13714R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining