ANKRD54,锚蛋白重复域54抗体
产品编号HZ-20549R
英文名称ANKRD54
中文名称锚蛋白重复域54抗体
别 名Ankrd54; ankyrin repeat domain 54; ankyrin repeat domain 54; Ankyrin repeat domain-containing protein 54; ANR54_HUMAN; LIAR.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
ANKRD54,锚蛋白重复域54抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量32kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ANKRD54
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ANKRD54,锚蛋白重复域54抗体PubMedPubMed
产品介绍background:
ANKRD54 is a 300 amino acid protein that contains four ankyrin repeats and is expressed as two alternatively spliced isoforms. The gene encoding human ANKRD54 maps to chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias.
Function:
Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.
Subunit:
Interacts (via ankyrin repeat region) with LYN (via SH3-domain) in an activation-independent status of LYN (By similarity). Forms a multiprotein complex with LYN and HCLS1. Interacts with TSN2, VAV1, DBNL AND LASP1.
ANKRD54,锚蛋白重复域54抗体Subcellular Location:
Nucleus. Cytoplasm. Midbody. Note=Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation.
Similarity:
Contains 4 ANK repeats.
Gene ID:
129138
Database links:
Entrez Gene: 129138 Human
Entrez Gene: 223690 Mouse
Entrez Gene: 362957 Rat
Omim: 613383 Human
SwissProt: Q6NXT1 Human
SwissProt: Q91WK7 Mouse
SwissProt: Q566C8 Rat
Unigene: 135259 Human
Unigene: 24262 Mous
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.